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Health and Wellness

By Ranu Boppana, MD

Nutrition and Mental Wellbeing

Recent research on nutrition is shedding new light on vitamins and minerals and their effects on health. While vitamins and their effects on physical health are widely reported, their effects on mental wellbeing are less often talked about. For example vitamin D, omega-3 fatty acids, folic acid and vitamin E recently have all been found to have effects on mental illnesses. Though the research is preliminary and the findings are the result of small studies, they are nonetheless exciting and promise to have consequences for the future treatment and prevention of mental illnesses.

Deficiency in Vitamin D, for example, was long known to cause rickets and with its eradication, vitamin D deficiency was thought to have been conquered. Recent research, however, is showing that Vitamin D is important not just for bone health but may help reduce the risk of some cancers, diabetes and multiple sclerosis, as well as depression and schizophrenia. Vitamin D receptors have been discovered in most cells throughout the body, and we are just learning how much vitamin D we really need and the role it plays in the health of other organs. Furthermore, by measuring the biologically active form of vitamin D in the bloodstreams of various populations, researchers have discovered that a deficiency in vitamin D is widespread, especially in those who live at higher latitudes or have darker skin. For example, according to several studies, greater than 40% of the elderly living in the United States may be deficient in vitamin D. Postmenopausal women taking medication for osteoporosis are likely to be deficient as well.

Vitamin D or “the sunshine vitamin” is made in our skin when we are exposed to UVB light, or we can get it from dietary sources such as fortified dairy products, orange juice, cereals, egg yolks, shiitake mushrooms, fatty fish or cod liver oil. Most fair-skinned individuals can get enough vitamin D in North America from spending 5 to 15 minutes in the sunlight each day during the summer. However, darker-skinned people, such as South Asians, may take up to six times longer. My father tells me that mustard-oil massages, outdoor exercise and sun exposure were a regular part of the daily ritual when he was growing up in India. No doubt, public awareness about the need to apply sunscreen to avoid sun damage and skin cancer has increased vitamin D deficiency, since sunscreens that block UVB rays block vitamin D production too. Adding vitamin D-rich foods to your diet will help make up for any deficiency.

Similarly, omega-3 essential fatty acids have been getting a lot of attention in the media these days for playing a role in cardiovascular health, but rarely talked about are the findings that they may also be helpful in mood disorders. Omegas 3s are essential fatty acids that our bodies can’t make and must be absorbed through food. The nutritionally essential omega-3 fatty acids include a-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Vegetarian sources of omega-3s such as flaxseed, walnuts and omega-3 eggs contain ALA which must then be synthesized by our bodies into EPA and DHA. Fatty fish and fish oil are good sources of EPA and DHA. South Asians who are vegetarians and who don’t eat fish may be particularly susceptible to an omega-3 deficiency. Furthermore, changes in our diet may have left us more susceptible. For example, my aunt tells me that ground flaxseed flour was a regular staple in the North Indian diet until people moved away from traditional foods and towards more refined ones.

Omega-3s, by the way, should not be confused with omega-6s which are found in vegetable oils. Omega-6s in fact are thought to produce molecules that are the precursors to inflammation such as prostaglandins. The ratio of omega-3s to omega-6s in your diet should be no higher than 4:1. Typical diets in America are between 10:1 and 30:1. Some studies have reported that countries with high rates of fish oil consumption have low rates of depressive disorders. Some studies have found that omega-3 supplementation may be helpful in the treatment and prevention of bipolar disorder and depression. One small study recently found that patients treated with both antidepressants and omega-3 supplementation did better than those who took antidepressants alone. Omega-3 fatty acids have been found to enhance the membranes of brain cells, helping the brain to repair damage by enhancing neuronal growth. This is also thought to change neurotransmitter function in the brain and is postulated to be the mechanism by which omega-3 supplementation is helpful in mood disorders.

Finally, there is evidence that folate and vitamin B12 supplementation may also be helpful in the treatment of depression. Vitamin E has also been postulated to have a role in preventing free radical damage that leads to Alzheimer’s. Certainly much more research is needed to fully understand how these vitamins and nutrients affect our mental wellbeing. However, there is much reason to believe that by doing so, we may lead to exciting ways of treating and preventing mental illnesses in the future.




Ranu Boppana, MD is a Board Certified Adult and Child Psychiatrist in private practice in New York City, New York. She is also a Clinical Instructor at the NYU School of Medicine and was included in the Consumer Research Council of America's "Guide to America's Top Psychiatrists 2007" Edition.

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